Chronic lack of sleep can negatively affect our immune cells, increasing certain health risks: new study

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Consistently losing an hour and a half of sleep each night can lead to inflammatory disorders and cardiovascular disease, according to a new study from the Icahn School of Medicine at Mount Sinai in New York City.

The study, published in the Journal of Experimental Medicine on Wednesday, September 21, 2022, found that a chronic lack of sleep could affect a person’s immune cells and contribute to inflammation in the body.

“Increased inflammation makes you susceptible to a whole bunch of problems, particularly cardiovascular disease,” co-researcher Cameron McAlpine, Ph.D., assistant professor of medicine (cardiology) at Icahn Mount, told Fox News Digital Sinai. an interview.

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McAlpine is one of the researchers who participated in the new study.

Lead author Filip Swirski, Ph.D., director of the Icahn Institute for Cardiovascular Research at Mount Sinai, said in a press release: “This work emphasizes the importance of adults getting consistent sleep seven to eight hours a day to help prevent inflammation and disease. especially for those with underlying medical conditions.”

Adults need seven to eight hours of sleep a night, said the lead author of a new study, “to help prevent inflammation and disease, especially for those with underlying medical conditions.”
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The researchers said the study begins to identify the body’s mechanisms that link sleep and long-term immune health.

The study revealed that in humans and mice, disrupted sleep can influence cellular programming and the rate of production of immune cells; this can cause immune cells to lose their effectiveness in protecting against disease.

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It can also affect the production rate of these cells and potentially make infections worse.

“Another key observation [is that] that sleep reduces inflammation and, conversely, that sleep disruption increases inflammation.”

The researchers also found disturbing evidence in the mouse model study that these effects may be long-lasting.

“This is important because it’s another key observation that sleep reduces inflammation, and conversely, that sleep disruption increases inflammation,” Swirski said in a press release.

McAlpine told Fox News Digital that the goal of the study was to better understand how chronic sleep disruption can affect cardiovascular conditions that develop over time due to inflammation.

A new study looked at the long-term effects of chronic sleep deprivation, compared to short-term sleep disruption for a few days.

A new study looked at the long-term effects of chronic sleep deprivation, compared to short-term sleep disruption for a few days.
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These findings, he said, may help with research involving other diseases and inflammatory conditions in the body, such as arthritis.

The study looked at the long-term effects of chronic sleep deprivation, McAlpine said, compared to a short-term disruption of sleep over a few days.

He said the study helped identify biological mechanisms and pathways linking sleep and immune system health over a long period.

The group of participants then reduced their sleep time by 90 minutes each night for six weeks, and had their blood drawn and reanalyzed.

The researchers looked at 14 healthy adults who regularly slept eight hours a night.

The participants were monitored at the beginning as they slept at least eight hours a night for six weeks. The team of researchers took blood samples and analyzed the participants’ immune cells.

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The group of participants then reduced their sleep time by 90 minutes each night for six weeks, and had their blood drawn and reanalyzed.

All 14 participants in a new study had “significant changes” in their immune cells that were attributed to lack of sleep, according to the findings.
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The researchers compared the blood samples and found that all 14 participants had significant changes in their immune cells that they attributed to lack of sleep.

Blood samples drawn from sleep showed altered DNA structure and increased numbers of immune cells.

Typically, in a heightened state of inflammation, health experts told Fox News Digital that there are increased numbers of immune cells.

The increased state of inflammation in mice that had fragmented sleep was not reversed even after sleep recovery, McAlpine also told Fox News Digital.

The researchers also looked at the effect of sleep disruption on the mice.

In the mice model, groups of mice were allowed to sleep undisturbed, while another group was awakened throughout the night for 16 weeks.

The mice in the interrupted sleep group then went through uninterrupted sleep recovery for 10 weeks, according to the report.

“Our results suggest that recovery sleep is not able to fully reverse the effects of poor quality sleep. We can detect a molecular imprint of insufficient sleep in immune stem cells, even after weeks of recovery sleep “.
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The research team analyzed immune stem cells and cells from groups of mice, and the findings were consistent with the human study, McAlpine said.

“We met at [both] human and mouse models [that] if you disturb sleep, you get increased inflammation in the blood.”

The increased state of inflammation in mice that had fragmented sleep was not reversed even after sleep recovery, McAlpine also told Fox News Digital.

Not all stem cells responded to sleep deprivation in the same way, he said.

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“Unfortunately, in the human study, we did not assess recovery, however [we] looked at recovery in mice. And in mice, we found that some parameters of inflammation returned to regular levels with sleep recovery, but not all.”

McAlpine said some cells remained (after recovery from sleep) that predisposed the mice to inflammation.

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In a press release, the co-researcher said: “Our findings suggest that sleep recovery is not able to completely reverse the effects of poor quality sleep. We can detect a molecular imprint of insufficient sleep in cells immune systems, even after weeks of sleep. restorative sleep. This … can cause cells to respond in inappropriate ways, leading to inflammation and disease.”

McAlpine told Fox News Digital that the research team plans further studies to understand which genes are being influenced by sleep, or gene pathways that may respond to sleep. This will allow researchers to understand the impacts of sleep in more detail.

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